2021 San Francisco 49ers Schedule

(12-8)
September 2021 -- Regular Season
Week Date Opponent Time TV Score
1 Sun., Sep. 12 @ Detroit Lions 10 a.m. FOX (W) 41-33
2 Sun., Sep. 19 @ Philadelphia Eagles 10 a.m. FOX (W) 17-11
3 Sun., Sep. 26 Green Bay Packers 5:20 p.m. NBC (L) 28-30
October 2021
Week Date Opponent Time TV Score
4 Sun., Oct. 3 Seattle Seahawks 1:05 p.m. FOX (L) 21-28
5 Sun., Oct. 10 @ Arizona Cardinals 1:25 p.m. FOX (L) 10-17
6 Sun., Oct. 17 BYE
7 Sun., Oct. 24 Baltimore Colts 5:20 p.m. NBC (L) 18-30
8 Sun., Oct. 31 @ Chicago Bears 10 a.m. FOX (W) 33-22
November 2021
Week Date Opponent Time TV Score
9 Sun., Nov. 7 Arizona Cardinals 1:25 p.m. FOX (L) 17-31
10 Mon., Nov. 15 Los Angeles Rams 5:15 p.m. ESPN (W) 31-10
11 Sun., Nov. 21 @ Jacksonville Jaguars 10 a.m. FOX (W) 30-10
12 Sun., Nov. 28 Minnesota Vikings 1:25 p.m. FOX (W) 34-26
December 2021
Week Date Opponent Time TV Score
13 Sun., Dec. 5 @ Seattle Seahawks 5:20 p.m. NBC (L) 23-30
14 Sun., Dec. 12 @ Cincinnati Bengals 10:00 a.m. CBS (W) 26-23, overtime
15 Sun., Dec. 19 Atlanta Falcons 1:05 p.m. CBS (W) 31-13
16 Thu, Dec. 23 @ Tennessee Titans 5:20 p.m. NFLN (L) 17-20
January 2022
Week Date Opponent Time TV Score
17 Sun., Jan. 2 Houston Texans 1:05 p.m. CBS (W) 23-7
18 Sun., Jan. 9 @ Los Angeles Rams 1:25 p.m. FOX (W) 27-24, OT
Playoffs - 2022
Week Date Opponent Time TV Score
19 Sun., Jan. 16 @ Dallas Cowboys 1:30 p.m. CBS, Paramount+, Nickelodeon, Amazon Prime Video (W) 23-17
20 Sat., Jan. 22 @ Green Bay Packers 5:15 p.m. FOX, Deportes (W) 13-10
21 Sun., Jan. 30 @ Los Angeles 3:30 p.m. FOX (L) 17-20
August 2021 -- Preseason
Week Date Opponent Time TV Score
1 Sat., Aug. 14 Kansas City Chiefs 5:30 p.m. KPIX (L) 16-19
2 Sun., Aug. 22 Los Angeles Chargers 4:30 p.m. KPIX (W) 15-10
3 Sun., Aug. 29 Las Vegas Raiders 1 p.m. KPIX (W) 34-10